HIV-1感染者血清IL-18及IL-18BP水平的变化及临床意义Clinical Significance of Changes of Interleuking-18 and Interleuking-18 Binding Protein Levels in Serum of HIV-infected Patients
黄甲清;张英;蒋就喜;胡婷婷;李赫伟;曾思恩;徐茹;沈建峰;谢付静;
摘要(Abstract)：
为了观察HIV-1阳性病人血清IL-18和IL-18BP水平与疾病的关系,用ELISA法检测67例经HAART治疗的HIV-1阳性病人及18例正常对照者血清的IL-18和IL-18BP水平。结果显示,HIV-1感染组血清IL-18水平明显高于正常对照组(P<0.01),其中A类HIV-1感染组IL-18水平高于正常对照组(P<0.05),B类、C类HIV-1感染组IL-18水平明显高于正常对照组(P<0.01);HIV-1感染组血清IL-18BP的水平明显高于正常人(P<0.01),其中各类HIV-1感染组IL-18BP水平均高于正常对照组(P<0.05);正常对照组IL-18和IL-18BP水平呈正相关(r=0.705,P<0.01),HIV-1感染组的IL-18和IL-18BP水平无相关性。可见,IL-18和IL-18BP水平的变化及失衡与艾滋病的发生、发展相关,动态监测外周血IL-18及IL-18BP水平可作为反映HIV-1感染者的免疫功能状态变化指标,调节体内IL-18、IL-18BP水平的平衡可能为艾滋病治疗提供新途径。
关键词(KeyWords)： HIV-1;白细胞介素-18;白细胞介素-18结合蛋白
基金项目(Foundation): 国家自然科学基金资助项目(30460141);; 广西本级技术研究与开发项目(桂财教[2010]124号,桂财教[2012]98号);; 广西教育厅科研项目(桂教科研[2007]34号);; 广西医疗卫生重点科研课题基金资助项目(重2010055);; 桂林市科学研究与技术开发项目(市科[2010]37号)
作者(Authors): 黄甲清;张英;蒋就喜;胡婷婷;李赫伟;曾思恩;徐茹;沈建峰;谢付静;
DOI: 10.16088/j.issn.1001-6600.2012.04.009
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